Directly north of the Magic Valley, the Salmon Region consists of Lemhi and Custer and portions of Blaine, and Valley counties. Big game hunt units include 21, 21a, 27, 28, 29, 30, 30a, 36, 36a, 36b, 37 and 37a. The regional office is located in Salmon.

Home to the "River of No Return," the Salmon river is one of the few undammed waterways left in America. The river and its forks serve as the only pathways into the Frank Church-River of No Return Wilderness area, the largest single federally designated wilderness in the lower 48. Hunters will find trophy elk, mule deer and antelope hunting and anglers can enjoy high mountain lake trout fishing.

Elevations in the Salmon Region reach up to 12,662 at Borah Peak, the highest peak in Idaho. Idaho record game harvest includes the number one Rocky Mountain goat taken in the Salmon Region.